Alprostadil Injection treatment of pulmonary heart disease observed 68 cases of heart failure


Xu Xiu n0usedriptoper onceperdayforays. ResOfthe6BB mother, 42easesweresignifica) Cdyimproved; 21casesweimprovedandaseswenotimprovedet adjoin alefficacyaw marriage 92.2% Chl mat I hat IEffect0fPGEintrenbn ~ atc0rpuI Ⅲ 0 coral deleanf ~ lureisreliableKEYWORDSPGE1Cot puzzle rrneHeart Cardiology hospital foundation ureEffectobservation l0 months 2OOO 1999 in May with alprostadil (alprostadil) Injection treatment of pulmonary heart disease heart failure (CHF) 68 patients achieved good clinical results, reported as follows. 1 Materials and Methods 1.1 volume data 68 patients hospitalized, 57 cases of male and female l3, aged 62 to 72 years, an average of 645 years old. With chronic bronchitis or chronic asthmatic bronchitis have a history of> 10a. Dyspnea, cyanosis, edema, hepatomegaly, jugular venous engorgement: pulmonary rales, and other signs. x-ray shows emphysema, prominent pulmonary artery segment, the lung-type ECG P wave, a large right ventricle, pulmonary resistance, mean arterial pressure around the display> 29nmdffg. Before the resistance increases right ventricular ejection, increased peripheral resistance, QB asked prolonged (> 30s), amplitude decreased pulmonary volume clinical diagnosis of pulmonary heart disease. l_2 treatment given anti-inflammatory, cough, asthma, diuretic therapy. In severe cases, to give fast digitalis preparations (cedilanid), with Kay 2o River when a 10% glucose injection 250. ~ In the intravenous drip, drip rate per minute ∞ ~ 30 drops, od, treatment . 1.3 Clinical Pán cream markedly: clinical symptoms and signs significantly reduced, laboratory tests, heart function improved> II level. A dare: Symptoms and signs partially mitigated, laboratory tests, heart function improved I level. Invalid: symptoms and signs are not reduced, cardiac function did not improve. Drum 2 Training results were 42 cases (618%), effective 2l cases (30.9%),moncler outlet, ineffective in 5 cases (7.3%), the total efficiency of 92.7%: 3 to discuss threat of heart failure due to pulmonary vascular disease resistance increases, the pulmonary artery wall thickening and ~ r [ff / J, arterial spasm, increase blood viscosity, blood volume increase caused by a variety of causes such as pulmonary hypertension, leading to right heart failure: humoral factors in the lack of which received oxygen pulmonary vascular Author: 253014 Dezhou City, Shandong Province, People's Hospital,ugg pas cher, Department of Pharmacy contraction plays an important role in arachidonic acid cyclooxygenase product prostaglandin and thromboxane has a strong contraction of blood vessels, the drug prostaglandin E1 relaxation of arterial smooth muscle directly, reduce pulmonary artery pressure, and inhibit platelet aggregation. Alprostadil mainly in the metabolism of the lungs J: intravenous drug in about 90% of the clams by pulmonary vascular metabolic inactivation, thus intravenous administration, the role of the pulmonary circulation is greater than the systemic circulation, there are results, PGE. Intravenous infusion of low concentrations can reduce pulmonary vascular resistance 28%,moncler jakker, total lung resistance by 32%, and cardiac index, and make blood vessels to increase oxygen content. Alprostadil treatment of pulmonary heart failure have a multifaceted role: ① direct confrontation prostaglandins. And thromboxane, the pulmonary expansion, reduce activities spicy vascular resistance, pulmonary blood circulation to increase the amount of alprostadil inhibits platelet aggregation, reduce blood nuts, lower right heart load, improve cardiac function. ② inhibition of norepinephrine and vasoconstrictor effects of angiotensin II, which peripheral expansion, lower blood pressure,abercrombie fitch paris, heart and reduce the load. ③ peripheral small blood vessels dilatation,ugg greece, significant improvement in beam tip circle; improve renal blood to win the amount of feces increased, improving cardiac function. ④ improve myocardial contractility and increase blood output and coronary blood flow. ⑤ direct relaxation of bronchial smooth muscle to airway expansion. Increased ventilation. Allow for sufficient oxygen, oxygen concentration, which both the heart and signs are useful. Summing up the progress, alprostadil is an effective treatment of pulmonary heart failure drugs can shorten the hospital stay the same, to reduce drug digitalis easily lead poisoning hazard, adverse reactions are skin wet red, headache, pain and redness of vascular infusion, slow free to reduce the drip rate, the patient can tolerate. e more a reference text desolate Wu Yan, Zhang Wenhai, agents Ping. Such as prostate and other tangled El myocardial ischemia damage to destroy the protective effect [1995; 34 (2): 982 Mao Huan Yuan, Yang Xintian. Cardiology [M]. Beijing People's Publishing House, 1995:706 (2001 eleven bite closing date of oath) (edit Li Xuan)