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Wang Tianxiang Liugui Feng ZNG Ai-lian Wang Xiaochong, experimental study on the toxic effects in rabbits. 【Key words】 Xiaozhi spirit; toxicity test; rabbit [CLC] R994.13 [Document code] A Xiaozhiling injection of a hardening agent in the treatment of three internal hemorrhoids 1] for the treatment of hemangioma to achieve a satisfactory effect of Ez. s3, but the drug injected into the vascular tumor cavity part of the liquid with the blood into the systemic circulation, have a direct injury to vascular endothelium, heart, liver, kidney and other vital organs, has paid close attention to. erefore, especially for Toxicity, provide the experimental basis for clinical use. A 1.1 object of the objects and methods provided by the Experimental Animal Center of Henan Province (2.5 ± 0.3) kg healthy white rabbits 18, female and male both 1.2 drugs Xiaozhiling injection from Beijing system pharmaceutical production, lidocaine produced by the Shanghai Fuxing Zhaohui Pharmaceutical Factory. 1.3 Methods rabbits were randomly divided into A, B, and C group, n = 6. A group Xiaozhiling dope, group B with a 4:1 solution (Xiaozhiling 4ml lidocaine lml), Group C with water for injection as a control. Rabbits in the experimental stage, through the ear vein injection of drugs, each rabbit every time the intravenous 2ml/kg (5 times the clinical dosage), Slow Note 1 ~ 2rain injected once weekly, daily clinical observation. e animals were sacrificed at the first injection of 1 and 2, respectively, to take the ear vein, heart, liver, kidney and histological observation. Observe the contents of: (1) were observed daily activities of the rabbits, ingestion, injection site skin and the presence of adverse reactions. ② anatomy of the naked eye the rabbit heart, liver, kidney or without exception. ③ the rabbit heart, liver, kidneys, veins and skin tissue for pathological examination. 2 Results 2.1 clinical observation, the activities of the group B rabbits, feeding with group C, no difference in each group no deaths. Group A 1, 3 B rabbit ear vein was punctured with a small amount of drug injected into the subcutaneous tissue, the rabbit pain and intense struggle 1 ~ 2rain. Subsequent swelling at the injection site skin tissue,Ugg Boots Günstig, blood stasis, 3 ~ swelling significantly, dark purple necrosis occurred at about 4, 6 ~ swelling disappeared, to the formation of local hard necrotizing dry spots. Group C, a rabbit of the unit: Henan Geological Hospital. Dermatology; Department of Pathology, Zhengzhou 450006; Department of Pharmacy, Shenyang Medical University, Shenyang, Liaoning 11OOl5 [Article ID 1009-6647 (2004) 04-0553-02 ear vein pierced with mild swelling, bleeding, 2 ~ swelling disappeared, leaving a dark purple bleeding spots. 2.2 the offal appearance and histopathology observed for groups A, B, heart, liver, kidney appearance and histopathological observation and the control group no difference, nor the ear vein endothelial cells microscopic abnormalities were found. Group A 1, 3, group B outer membrane of the rabbit's ear vein a small amount of inflammatory cell infiltration, perivascular subcutaneous tissue showed diffuse interstitial edema, lymphocyte infiltration and fibrous tissue proliferation and focal necrosis, while e control group had no pathological changes. 3 to discuss Xiaozhiling injection made by the active ingredients of traditional Chinese medicine gall,moncler danmark, alum, etc.. By animal experiments and clinical application. ] Proved that local organizations strong aseptic proinflammatory, antimicrobial, convergence, protein coagulation, tissue fibrosis, the role of treatment of internal hemorrhoids, hemangioma is an ideal hardening agent. However, in clinical treatment, the drug into the systemic circulation if other important tissues and organs has a direct injury, is still worrying. is experiment will eliminate the the Hemorrhoid liquid and a 4:1 solution of rabbit vein injection, each 2ml/kg (5 times the clinical use of drugs), weekly, once every two and four. e results showed that the behavior of all rabbits,moncler sale online, feeding conditions and the control group, no differences in histopathological observation vein endothelial cells, heart, liver, kidney and the control group showed no abnormal changes. It is noteworthy that the strongest parts of the injection at the venous endothelial drug effect was not found damage,ugg pas cher, clinical reports, the EI-33 drug injected into the hemorrhoids,canada goose jakke, the role played by the vascular aneurysm does not match the analysis of the reasons drug injected into a vein soon after the circulation of blood diluted drug concentrations were significantly lower, and will not damage the endothelial cells and other vital organs of the body. And clinical treatment of different drugs injected into the hemorrhoids or hemangioma cavity into the surrounding tissue play a drug effect, play the source and path blocking the blood flow of internal hemorrhoids, or hemangioma, the tumor cavity to maintain a high concentration the drug for a long time to play a role, but for therapeutic purposes. e results suggest that: 5 times the clinical dosage Xiaozhiling injection into the human circulatory no damage to vital organs of the body, suggesting that application of the drug treatment of vascular tumors is safe. However, the experimental group, four rabbits (group A 1, B 3) ear vein punctured