Amrinone combined with nifedipine treatment of chronic pulmonary heart disease refractory heart failure (21 Cases)


Respiratory tract infections, improve hypoxia and hypercapnia, with cardiac,ralph lauren online, diuretic therapy, and more control. But its very late stage disease is often complex and often complicated by the whole heart failure, coupled with a long period of hypoxia,abercrombie uk, the low tolerance of digitalis drugs, therapeutic dose and toxic dose is very close to, prone to toxicity, causing severe arrhythmia. Therefore, when faced with repeated application of digitalis and diuretics and heart failure is not corrected, may be appropriate to the child other non-digitalis inotropic drugs, heart failure can often be controlled, the group with the power of nifedipine and ammonia agricultural treatment, and achieved satisfactory results. Amrinone is a new non-digitalis inotropic drug,diesel online, its mechanism of action is inhibition of phosphodiester isoenzyme III, the decomposition of reduced CAMP, intracellular CAMP concentration, activation of protein kinase, the cell membrane calcium channel protein phosphorylation, increased calcium influx, play positive inotropic effect. While the direct relaxation of vascular smooth muscle, reducing the load before and after the heart '; direct expansion of the coronary artery, increased myocardial blood flow and improve cardiac function pressure was significantly lower, and can reduce the myocardial oxygen consumption index, increased cardiac output, cardiac index and cardiac index] According to the literature there are some amrinone diuretic l. Nifedipine is a calcium antagonists, by inhibiting calcium influx in the cell membrane, directly on vascular smooth muscle, can be more specific to the expansion of the lung blood vessels, reducing pulmonary artery pressure, increased pulmonary blood flow, alleviate hypoxic pulmonary vascular spasm, increased right ventricular load without under the premise of increased cardiac output in order to improve tissue oxygen while also with active vascular smooth muscle relaxation, improve the ventilation effect. amrinone and nifedipine in combination, can come from different aspects of peripheral expansion, a significant reduction in cardiac after the load,ugg boots norge, the diuretic effects of amrinone, but also further reduce the preload, the positive inotropic effect of nifedipine offset weak negative inotropic effect, improved systolic and diastolic function, so that cardiac output increased significantly, which play in the treatment of heart failure, the synergy of two drugs to achieve better outcomes than a single drug, therefore,abercrombie & fitch, the authors believe that the short-term effects from treatment and comprehensive analysis of adverse reactions, amrinone combined nifedipine treatment of chronic lung heart disease refractory heart failure is reasonable and effective, is worthy of promotion, but the exact long-term efficacy of the application of the two drugs remains to be further explored.